Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans
نویسندگان
چکیده
منابع مشابه
genetic susceptibility of angiotensin-i converting enzyme and g-protein β3-subunit gene polymorphisms to essential hypertension
essential hypertension (eh) accounts for 90-95% of hypertension cases. eh, as a progressive cardiovascular syndrome arising from complex and interrelated etiologies, results from combined and interactive effects of genetic and environmental factors. the objective was to investigate the ace i/d and gnb3 c825t polymorphisms and both genotypes combined with seeking gene-gene interactions to furthe...
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BACKGROUND The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene (ACE) and the C825T polymorphism in the G-protein β3 subunit gene (GNB3) are associated with the efficacy of phosphodiesterase-5 inhibitor (PDE-5I) in erectile dysfunction. In addition, GNB3 genotypes could be associated with clinical worsening in pulmonary hypertension (PH) treated with PDE-5I. Howev...
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OBJECTIVE The G protein is responsible for signal intracellular transduction and participates in cardiovascular reflexes. C825T polymorphism of the gene encodes the B3 subunit of G protein (GNB3) and causes the increased intracellular signal transduction. The aim was the evaluation GNB3 C825T polymorphism manifestation in vasovagal patients with no other diseases. METHODS In 68 positive tilte...
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BACKGROUND The guanine nucleotide-binding protein beta polypeptide 3 (GNB3) 825T allele encodes a product that enhances the activation of heterotrimeric G proteins, which is associated with the occurrence of the splice variant Gβ3 s that could play a role in vascular reactivity and hyperproliferation of smooth muscle cells, that makes such proteins attractive candidate gene products for suscept...
متن کاملAssociation of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension
The role of G-protein activation in cardiovascular disorders is well-known. G-protein β3 subunit (GNB3) C825T polymorphism is associated with increased intracellular signal transduction. We investigated the role of the variant in plasma sodium and potassium concentrations and association with hypertension. 345 healthy controls and 455 patients with essential hypertension were enrolled. Plasma r...
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ژورنال
عنوان ژورنال: Journal of Human Hypertension
سال: 2006
ISSN: 0950-9240,1476-5527
DOI: 10.1038/sj.jhh.1002110